Kimmel Susan E, Ward Cynthia R, Henthorn Paula S, Hess Rebecka S
Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
J Am Anim Hosp Assoc. 2002 May-Jun;38(3):235-8. doi: 10.5326/0380235.
Five adult Samoyed dogs from two unrelated litters were diagnosed with diabetes mellitus. Two full-sibling male dogs (Family A) were raised in the same household. The other three dogs, two female and one male, were also full siblings (Family B) raised in different households. All five dogs developed polyuria and polydipsia and demonstrated fasting hyperglycemia and glucosuria. Diabetes mellitus was diagnosed in all five dogs and responded to appropriate therapy with insulin. The occurrence of insulin-dependent diabetes mellitus in multiple, closely related Samoyed dogs suggests a familial predisposition in this breed.
来自两窝无亲缘关系的五只成年萨摩耶犬被诊断患有糖尿病。两只全同胞雄性犬（A家族）在同一家庭中饲养。另外三只犬，两雌一雄，也是全同胞（B家族），分别在不同家庭中饲养。所有五只犬均出现多尿和多饮症状，并表现出空腹血糖升高和糖尿。五只犬均被诊断为糖尿病，并对胰岛素的适当治疗有反应。多只亲缘关系密切的萨摩耶犬发生胰岛素依赖型糖尿病表明该品种存在家族易感性。
