Kramer J W, Klaassen J K, Baskin D G, Prieur D J, Rantanen N W, Robinette J D, Graber W R, Rashti L
College of Veterinary Medicine, Washington State University, Pullman 99164.
Am J Vet Res. 1988 Mar;49(3):428-31.
The genetic aspects of inherited, insulin-dependent diabetes mellitus of Keeshond dogs were studied retrospectively and in a prospective mating program. The symbol dm was used to designate the gene that causes hypoplasia of the islets of Langerhans. The retrospective study disclosed 4 diabetic dogs; prospective outcross, backcross, and inbred matings disclosed 49 diabetic dogs. Outcrossing demonstrated that the diabetic phenotype was displayed readily against a genetic background of a breed other than the Keeshond. In dogs with the dm/dm genotype, onset of diabetes was most frequent before the dog was 6 months old, but did occur in some older dogs. The dm genotype was best described as autosomal recessive.
对荷兰毛狮犬遗传性胰岛素依赖型糖尿病的遗传因素进行了回顾性研究，并开展了一项前瞻性配种计划。符号dm用于表示导致朗格汉斯岛发育不全的基因。回顾性研究发现了4只患糖尿病的犬；前瞻性杂交、回交和近交配种发现了49只患糖尿病的犬。杂交表明，在除荷兰毛狮犬以外的其他品种的遗传背景下，糖尿病表型很容易表现出来。在基因型为dm/dm的犬中，糖尿病最常在犬6月龄前发病，但也有一些年龄较大的犬发病。dm基因型最好描述为常染色体隐性遗传。
