[胰岛素对不同年龄大鼠肝脏染色质组分中RNA生物合成的影响]
[Effect of insulin on RNA biosynthesis in the chromatin fractions of the liver of rats of different age].
作者信息
Khilobok I Iu, Khil'ko O K, Gol'dshteĭn N B, Frantseva T G
出版信息
Probl Endokrinol (Mosk). 1977 May-Jun;23(3):84-6.
Experiments were conducted on rats; a study was made of the age changes of insulin action on the genetic apparatus of hepatocytes. Adult (6-8-month-old) rats showed the greatest elevation of transcribing capacity of the repressed chromatin fraction 2 hours after the hormone administration, no changes occurred in the active chromatin fraction. The maximum increase of the labeled precursor inclusion in old (24--26-month-old) rats was seen 3 hours after insulin injection both in repressed and active chromatin.
在大鼠身上进行了实验；研究了胰岛素对肝细胞遗传装置作用的年龄变化。成年（6 - 8个月大）大鼠在给予激素后2小时，其受抑制染色质部分的转录能力升高最为显著，而活性染色质部分未发生变化。在老年（24 - 26个月大）大鼠中，胰岛素注射后3小时，无论是受抑制染色质还是活性染色质，标记前体掺入量均出现最大增幅。
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