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恰加斯病中心脏损伤的免疫病理机制

Immunopathological Mechanisms Underlying Cardiac Damage in Chagas Disease.

作者信息

De Alba-Alvarado Mariana Citlalli, Torres-Gutiérrez Elia, Reynoso-Ducoing Olivia Alicia, Zenteno-Galindo Edgar, Cabrera-Bravo Margarita, Guevara-Gómez Yolanda, Salazar-Schettino Paz María, Rivera-Fernández Norma, Bucio-Torres Martha Irene

机构信息

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, México City 04510, Mexico.

Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, México City 04510, Mexico.

出版信息

Pathogens. 2023 Feb 16;12(2):335. doi: 10.3390/pathogens12020335.

DOI:10.3390/pathogens12020335
PMID:36839607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9959418/
Abstract

In Chagas disease, the mechanisms involved in cardiac damage are an active field of study. The factors underlying the evolution of lesions following infection by and, in some cases, the persistence of its antigens and the host response, with the ensuing development of clinically observable cardiac damage, are analyzed in this review.

摘要

在恰加斯病中，心脏损伤所涉及的机制是一个活跃的研究领域。本综述分析了感染后病变演变的潜在因素，以及在某些情况下其抗原的持续存在和宿主反应，以及随之而来的临床上可观察到的心脏损伤的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb95/9959418/04e2865a2dcb/pathogens-12-00335-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb95/9959418/04e2865a2dcb/pathogens-12-00335-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb95/9959418/04e2865a2dcb/pathogens-12-00335-g001.jpg

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本文引用的文献

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Global, Regional, and National Trends of Chagas Disease from 1990 to 2019: Comprehensive Analysis of the Global Burden of Disease Study.全球、区域和国家 1990 年至 2019 年查加斯病趋势：全球疾病负担研究综合分析。
Glob Heart. 2022 Aug 24;17(1):59. doi: 10.5334/gh.1150. eCollection 2022.
2
Endocytic Rabs Are Recruited to the Parasitophorous Vacuole and Contribute to the Process of Infection in Non-professional Phagocytic Cells.内吞性Rabs蛋白被募集到寄生泡，并参与非专职吞噬细胞的感染过程。
Front Cell Infect Microbiol. 2020 Oct 29;10:536985. doi: 10.3389/fcimb.2020.536985. eCollection 2020.
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Response to Infection by in a Murine Model.
多种克隆的共感染：宿主 - 寄生虫关系的新视角及其对恰加斯病发病机制和管理的影响
Microbiol Mol Biol Rev. 2025 Jun 25;89(2):e0024224. doi: 10.1128/mmbr.00242-24. Epub 2025 Mar 21.
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Pathogens. 2024 Oct 3;13(10):870. doi: 10.3390/pathogens13100870.
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Editorial: Early events during host cell-pathogen interaction, volume II.社论：宿主细胞与病原体相互作用早期事件，第二卷。
Front Cell Infect Microbiol. 2024 Jan 17;14:1364415. doi: 10.3389/fcimb.2024.1364415. eCollection 2024.
6
Immunopathogenesis in infection: a role for suppressed macrophages and apoptotic cells.感染的免疫发病机制：受抑制的巨噬细胞和凋亡细胞的作用。
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