Walzer C, Huber C
Salzburg Zoo Hellbrunn, A-5081 Anif, Austria.
J Wildl Dis. 2002 Apr;38(2):468-72. doi: 10.7589/0090-3558-38.2.468.
This study evaluated partial antagonism of tiletamine-zolazepam (TZ) anesthesia in cheetahs (Acinonyx jubatus) and differences between two benzodiazepine antagonists, flumazenil and sarmazenil, in this species. Four cheetahs were anesthetized three times at an interval of 14 days with an average intramuscular dose of 4.2 mg/kg TZ. In trials 2 and 3 flumazenil at 0.031 mg/kg and sarmazenil at 0.1 mg/kg, respectively, were applied intramuscularly 30 min after initial TZ injection. There was a highly significant difference between the duration of TZ anesthesia with and without antagonist. Use of the antagonists significantly shortened duration and recovery and eliminated excitatory behavior during the recovery phase. No significant differences could be determined between the two antagonists. We recommend the use of sarmazenil and flumazenil to antagonize TZ anesthesia in cheetahs.
本研究评估了替来他明-唑拉西泮（TZ）麻醉在猎豹（Acinonyx jubatus）中的部分拮抗作用，以及两种苯二氮䓬拮抗剂氟马西尼和沙马西尼在该物种中的差异。四只猎豹每隔14天接受三次麻醉，平均肌肉注射剂量为4.2mg/kg TZ。在试验2和试验3中，分别在首次注射TZ后30分钟肌肉注射0.031mg/kg的氟马西尼和0.1mg/kg的沙马西尼。使用拮抗剂和未使用拮抗剂的情况下，TZ麻醉持续时间存在高度显著差异。使用拮抗剂显著缩短了麻醉持续时间和恢复时间，并消除了恢复阶段的兴奋行为。两种拮抗剂之间未发现显著差异。我们建议使用沙马西尼和氟马西尼来拮抗猎豹的TZ麻醉。
