Singer Andrew L, Koretzky Gary A
The Abramson Family Cancer Research Institute, Department of Laboratory Medicine and Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Science. 2002 May 31;296(5573):1639-40. doi: 10.1126/science.1071551.
T cells are an essential element of the body's immune system. Engagement of the T cell receptor is responsible for initiating the signaling events that can activate, inactivate, or eliminate T cells, depending on the magnitude and duration of the signal. Control of T cell signaling occurs through both positive and negative regulation, as well as through the actions of molecular scaffolds that contribute to the formation of signaling complexes. The T Cell Signal Transduction Pathway at the STKE Connections Maps highlights the molecular components that are responsible for T cell activation. Understanding the mechanisms that regulate T cell responsiveness will aid in the development of therapeutic agents to treat infection, cancer, and autoimmune disease and immune deficiency.
T细胞是人体免疫系统的重要组成部分。T细胞受体的激活负责启动信号传导事件，这些事件可根据信号的强度和持续时间激活、失活或消除T细胞。T细胞信号传导的控制通过正调控和负调控以及有助于信号复合物形成的分子支架的作用来实现。STKE连接图谱中的T细胞信号转导途径突出了负责T细胞激活的分子成分。了解调节T细胞反应性的机制将有助于开发治疗感染、癌症、自身免疫性疾病和免疫缺陷的治疗药物。
