Li J Y, Zhu J C, Dou J T, Bai W J, Deng S M, Li M, Huang W, Jin H
Department of Endocrinology, Beijing 301 Hospital, 28 Fuxing Road, Beijing 100853, People's Republic of China.
Aging Male. 2002 Mar;5(1):47-51.
To assess the responses of a symptom complex related to partial androgen deficiency in the aging male (PADAM) to androgen supplementation.
Eighty-six men from five hospitals in Beijing aged 50-70 years with symptoms related to PADAM received oral testosterone undecanoate for 2 months, and the effects of the therapy were evaluated.
After treatment, the symptom scores were significantly improved (all p < 0.001). Serum levels of luteinizing hormone and follicle stimulating hormone were suppressed, and free testosterone and albumin-bound testosterone levels were elevated. However, they were not significantly different from the pretreatment values. Waist/hip ratio and blood pressure were markedly decreased, but no changes were found in serum levels of total cholesterol, triglyceride, albumin and prostate specific antigen.
Two months of treatment with oral testosterone undecanoate clearly improved the symptoms related to PADAM. No statistical relationship was found between symptom improvement and androgen levels. Androgen therapy for 2 months was beneficial to the waist/hip ratio and blood pressure, and no harm was done to the prostate gland or lipid metabolism.
评估与老年男性部分雄激素缺乏（PADAM）相关的症状复合体对雄激素补充的反应。
来自北京五家医院的86名年龄在50 - 70岁、有PADAM相关症状的男性接受了2个月的十一酸睾酮口服治疗，并对治疗效果进行评估。
治疗后，症状评分显著改善（所有p < 0.001）。血清促黄体生成素和促卵泡生成素水平受到抑制，游离睾酮和白蛋白结合睾酮水平升高。然而，它们与治疗前的值无显著差异。腰臀比和血压明显降低，但血清总胆固醇、甘油三酯、白蛋白和前列腺特异性抗原水平无变化。
口服十一酸睾酮治疗2个月明显改善了与PADAM相关的症状。症状改善与雄激素水平之间未发现统计学关系。2个月的雄激素治疗对腰臀比和血压有益，对前列腺或脂质代谢无损害。
