Woźniak A, Drewa T, Rozwodowska M, Drewa G, Lambrecht W, Wiśniewska I
Department of Biology, Ludwik Rydygier Medical University, Bydgoszcz, Poland.
Neoplasma. 2002;49(1):10-5.
The aim of the study was an assessment of some lysosomal enzymes activity in serum and in tumors of patients with lung cancer histopathologically confirmed as squamous cell lung carcinoma. The first group constisted of 10 patients with stage II of the disease and the second group consisted of 11 patients with stage III of the disease. Lysosomal enzymes activities were assayed in serum before surgery and on the 10th day after surgery in serum and in tumors. Arylsuphatase, cathepsin D and acid phosphatase activities were higher in the patients serum than in that of the control group. The decrease of arylsulphatase and cathepsin D activities after surgery was statistically significant in both groups of patients, but the cathepsin D activity was still 3 times higher in patients than in those from the control group. The decrease of acid phosphatase activity after surgery was about 50% in both groups of patients and this decrease was statistically significant. The arylsulphatase and acid phosphatase activity in tumors was nearly 3 times higher in stage III patients than it was in stage II patients, but the cathepsin D activity was nearly the same in both patient groups. Higher lysosomal enzyme activity may be a useful factor in diagnosing and monitoring of lung cancer. However, further investigations are needed.
本研究旨在评估经组织病理学确诊为肺鳞状细胞癌患者血清及肿瘤组织中某些溶酶体酶的活性。第一组由10例疾病分期为II期的患者组成，第二组由11例疾病分期为III期的患者组成。在手术前、手术后第10天分别测定血清及肿瘤组织中溶酶体酶的活性。患者血清中芳基硫酸酯酶、组织蛋白酶D和酸性磷酸酶的活性高于对照组。两组患者术后芳基硫酸酯酶和组织蛋白酶D活性的降低具有统计学意义，但患者组组织蛋白酶D活性仍比对照组高3倍。两组患者术后酸性磷酸酶活性降低约50%，且这种降低具有统计学意义。III期患者肿瘤组织中芳基硫酸酯酶和酸性磷酸酶的活性比II期患者高近3倍，但两组患者组织蛋白酶D的活性几乎相同。较高的溶酶体酶活性可能是诊断和监测肺癌的一个有用因素。然而，还需要进一步的研究。
