Mariani L
Eur J Toxicol Environ Hyg. 1975 Nov-Dec;8(6):335-9.
The influence of various experimental conditions such as partial hepatectomy, administration of hepatotoxic drugs such as carbontetrachloride or ethionine, and starvation on the ulcerogenic activity of indomethacin at intestinal level has been studied in the rat. While lesions produced by oral administration of high doses of indomethacin are reduced by starvation, the incidence of ulcers was significantly increased by partial hepatectomy and by hepatotoxic drugs reaching the maximum of severity (intestinal perforation) in partially hepatectomized animals. These findings suggest that ulcerogenic activity of indomethacin is strictly correlated to the drug metabolising capacity of the liver.
在大鼠中研究了各种实验条件，如部分肝切除术、给予肝毒性药物（如四氯化碳或乙硫氨酸）以及饥饿对吲哚美辛在肠道水平致溃疡活性的影响。口服高剂量吲哚美辛产生的损伤会因饥饿而减轻，但部分肝切除术和肝毒性药物会显著增加溃疡的发生率，在部分肝切除的动物中溃疡严重程度达到最高（肠穿孔）。这些发现表明，吲哚美辛的致溃疡活性与肝脏的药物代谢能力密切相关。
