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皮质酮对地塞米松反馈作用的影响。

Effect of cortexolone on the feedback action of dexamethasone.

作者信息

Acs Z, Stark E

出版信息

Experientia. 1975 Nov 15;31(11):1365-6. doi: 10.1007/BF01945830.

DOI:10.1007/BF01945830
PMID:1204804
Abstract

Cortexolone in a dose of 1 mg/100 g body wt., administered to rats prior to dexamethasone, prevented dexamethasone from suppressing stress-induced ACTH-release without interfering with the effect of dexamethasone on the resting plasma corticosterone level.

摘要

在给大鼠注射地塞米松之前，以1毫克/100克体重的剂量注射皮质酮，可防止地塞米松抑制应激诱导的促肾上腺皮质激素释放，同时不干扰地塞米松对静息血浆皮质酮水平的影响。

相似文献

1
Effect of cortexolone on the feedback action of dexamethasone.皮质酮对地塞米松反馈作用的影响。
Experientia. 1975 Nov 15;31(11):1365-6. doi: 10.1007/BF01945830.
2
[Cortexolone as a modulator of diazepam activity].[皮质酮作为地西泮活性的调节剂]
Biull Eksp Biol Med. 1987 Jun;103(6):675-6.
3
Antiglucocorticoids: in vivo assay and evaluation of cortexolone, progesterone, and 6-beta-bromoprogesterone.抗糖皮质激素：皮质酮、孕酮和6-β-溴孕酮的体内试验与评价
Endocrinology. 1980 Jul;107(1):117-21. doi: 10.1210/endo-107-1-117.
4
11-Deoxycortisol induces hepatic tryptophan oxygenase in rats.11-脱氧皮质醇诱导大鼠肝脏色氨酸加氧酶。
Acta Pharmacol Toxicol (Copenh). 1985 Jul;57(1):36-9. doi: 10.1111/j.1600-0773.1985.tb00006.x.
5
Autoradiographic localization of 3H-glucocorticoids and 3H-cortexolone in mouse pituitary.小鼠垂体中3H-糖皮质激素和3H-皮质酮的放射自显影定位
Cell Tissue Res. 1979 Aug;200(2):311-22. doi: 10.1007/BF00236423.
6
Effect of antiglucocorticoids on dexamethasone-induced inhibition of uridine incorporation and cell lysis in isolated mouse thymocytes.抗糖皮质激素对离体小鼠胸腺细胞中地塞米松诱导的尿苷掺入抑制及细胞裂解的影响。
J Steroid Biochem. 1984 Jan;20(1):283-7. doi: 10.1016/0022-4731(84)90218-8.
7
11-Deoxycortisol: a glucocorticoid antagonist in vivo.11-脱氧皮质醇：一种体内的糖皮质激素拮抗剂。
Endocrinology. 1979 Jun;104(6):1839-44. doi: 10.1210/endo-104-6-1839.
8
Autoradiographic studies of a glucocorticoid agonist and antagonist: localization of 3H-corticosterone and 3H-cortexolone in mouse brain.一种糖皮质激素激动剂和拮抗剂的放射自显影研究：3H-皮质酮和3H-皮质醇在小鼠脑中的定位。
Cell Tissue Res. 1979 Apr 12;197(3):531-8. doi: 10.1007/BF00233575.
9
Cortexolone antagonizes development of alcohol tolerance in mice.皮质酮可拮抗小鼠酒精耐受性的发展。
Psychopharmacology (Berl). 1979 Jun 28;64(1):123-4. doi: 10.1007/BF00427357.
10
Regulation of transcription in rat thymus cells by glucocorticoids.糖皮质激素对大鼠胸腺细胞转录的调控。
J Steroid Biochem. 1979 Jul;11(1B):381-7. doi: 10.1016/0022-4731(79)90056-6.

引用本文的文献

1
Effect of intravenous infusions of corticosterone and 11-deoxycortisol on the plasma glucocorticoid profile in normal adult subjects.
J Endocrinol Invest. 1979 Apr-Jun;2(2):151-8. doi: 10.1007/BF03349307.
2
Autoradiographic localization of 3H-glucocorticoids and 3H-cortexolone in mouse pituitary.小鼠垂体中3H-糖皮质激素和3H-皮质酮的放射自显影定位
Cell Tissue Res. 1979 Aug;200(2):311-22. doi: 10.1007/BF00236423.
3
Autoradiographic studies of a glucocorticoid agonist and antagonist: localization of 3H-corticosterone and 3H-cortexolone in mouse brain.一种糖皮质激素激动剂和拮抗剂的放射自显影研究：3H-皮质酮和3H-皮质醇在小鼠脑中的定位。

本文引用的文献

1
Negative feedback and pituitary-adrenal function in female rats.雌性大鼠的负反馈与垂体-肾上腺功能
Am J Physiol. 1969 Jan;216(1):148-55. doi: 10.1152/ajplegacy.1969.216.1.148.
2
Specific and nonspecific physicochemical interactions of glucocorticoids and related steroids with rat thymus cells in vitro.糖皮质激素及相关甾体与大鼠胸腺细胞在体外的特异性和非特异性物理化学相互作用
J Biol Chem. 1968 Nov 10;243(21):5556-65.
3
Corticosterone binding by rat brain cytosol.大鼠脑细胞质中皮质酮的结合
Cell Tissue Res. 1979 Apr 12;197(3):531-8. doi: 10.1007/BF00233575.
4
Differential and integral corticosteroid feedback effects on ACTH secretion in hypoadrenocorticism.肾上腺皮质功能减退症中皮质类固醇对促肾上腺皮质激素分泌的差异及整合反馈作用
J Clin Invest. 1979 Feb;63(2):247-53. doi: 10.1172/JCI109296.
J Neurochem. 1971 Sep;18(9):1725-32. doi: 10.1111/j.1471-4159.1971.tb03747.x.
4
Evidence for irreversible, actinomycin D-sensitive, and temperature-sensitive steps following binding of cortisol to glucocorticoid receptors and preceding effects on glucose metabolism in rat thymus cells.在大鼠胸腺细胞中，皮质醇与糖皮质激素受体结合后，以及对葡萄糖代谢产生影响之前，存在不可逆、对放线菌素D敏感且对温度敏感步骤的证据。
J Biol Chem. 1971 Feb 10;246(3):654-9.
5
Uptake of corticosterone by rat brain and its concentration by certain limbic structures.大鼠脑对皮质酮的摄取及其在某些边缘结构中的浓度。
Brain Res. 1969 Nov;16(1):227-41. doi: 10.1016/0006-8993(69)90096-1.
6
The hippocampus and septal area as primary target sites for corticosterone.海马体和隔区作为皮质酮的主要靶位点。
J Neurochem. 1972 Dec;19(12):2737-45. doi: 10.1111/j.1471-4159.1972.tb03811.x.
7
Cortexolone: binding to glucocorticoid receptors in rat thymocytes and mechanism of its antiglucocorticoid action.皮质酮：与大鼠胸腺细胞中糖皮质激素受体的结合及其抗糖皮质激素作用机制
Biochem Biophys Res Commun. 1972 Oct 17;49(2):516-21. doi: 10.1016/0006-291x(72)90441-x.
8
Evidence for dual corticosteroid-receptor mechanisms in the feedback control of adrenocorticotrophin secretion.促肾上腺皮质激素分泌反馈控制中双重皮质类固醇受体机制的证据。
J Endocrinol. 1974 Feb;60(2):223-33. doi: 10.1677/joe.0.0600223.
9
The hypothalamus and pituitary ACTH release.下丘脑与垂体促肾上腺皮质激素释放。
Prog Brain Res. 1970;32:12-20. doi: 10.1016/S0079-6123(08)61514-9.
10
Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.一些关于类固醇蛋白质结合的研究及其在通过竞争性蛋白质结合放射分析法对体液中各种类固醇进行常规微量和超微量测量中的应用。
J Clin Endocrinol Metab. 1967 Jul;27(7):973-90. doi: 10.1210/jcem-27-7-973.