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Clinical trials of treatments for stroke.

作者信息

Blass John

机构信息

Department of Neurology and Medicine, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.

出版信息

Curr Atheroscler Rep. 2002 Jul;4(4):265-9. doi: 10.1007/s11883-002-0004-8.

DOI:10.1007/s11883-002-0004-8
PMID:12052276
Abstract

The "gold standard" for therapeutic trials is the prospective, double-blind, placebo-controlled, multicenter trial. However, they are relatively clumsy instruments for discovering innovative new treatments. This article briefly reviews selected clinical trials of treatments for stroke, including stroke rehabilitation, published during 2001 and the first 2 months of 2002. It also reviews other types of studies, including close observations of single patients, which can have a valuable role in generating useful new knowledge.

摘要

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本文引用的文献

1
A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke.华法林与阿司匹林预防复发性缺血性卒中的比较。
N Engl J Med. 2001 Nov 15;345(20):1444-51. doi: 10.1056/NEJMoa011258.
2
Extending tissue plasminogen activator use to community and rural stroke patients.将组织纤溶酶原激活剂的应用扩展至社区及农村中风患者。
Stroke. 2002 Jan;33(1):141-6. doi: 10.1161/hs0102.100481.
3
Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial.对乙酰氨基酚用于改变急性卒中患者体温:一项随机临床试验
Stroke. 2002 Jan;33(1):130-4. doi: 10.1161/hs0102.101477.
4
Bleeding risk of tirofiban, a nonpeptide GPIIb/IIIa platelet receptor antagonist in progressive stroke: an open pilot study.替罗非班(一种非肽类糖蛋白IIb/IIIa血小板受体拮抗剂)在进展性卒中中的出血风险:一项开放性初步研究。
Cerebrovasc Dis. 2001;12(4):308-12. doi: 10.1159/000047726.
5
Carotid angioplasty and stenting versus carotid endarterectomy: randomized trial in a community hospital.颈动脉血管成形术和支架置入术与颈动脉内膜切除术的比较:社区医院的随机试验
J Am Coll Cardiol. 2001 Nov 15;38(6):1589-95. doi: 10.1016/s0735-1097(01)01595-9.
6
A clinical trial of estrogen-replacement therapy after ischemic stroke.缺血性中风后雌激素替代疗法的一项临床试验。
N Engl J Med. 2001 Oct 25;345(17):1243-9. doi: 10.1056/NEJMoa010534.
7
Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial.抗细胞间黏附分子-1疗法在缺血性卒中中的应用:恩利单抗急性卒中试验结果
Neurology. 2001 Oct 23;57(8):1428-34. doi: 10.1212/wnl.57.8.1428.
8
A double-blind placebo-controlled study of the effects of amphetamine and physiotherapy after stroke.
Cerebrovasc Dis. 2001;12(3):253-7. doi: 10.1159/000047712.
9
Post-stroke violent adventitial movement responsive to levo-dopa/carbi-dopa therapy.中风后暴力性血管外膜运动对左旋多巴/卡比多巴治疗有反应。
Brain Inj. 2001 Oct;15(10):911-6. doi: 10.1080/02699050110063468.
10
Treatment of ballism and pseudobulbar affect with sertraline.舍曲林治疗颤搐症和假性延髓情绪障碍
Arch Neurol. 2001 Oct;58(10):1682-4. doi: 10.1001/archneur.58.10.1682.