a Department of Neurology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Expert Rev Neurother. 2017 Nov;17(11):1091-1107. doi: 10.1080/14737175.2017.1373020. Epub 2017 Sep 8.
Aphasia is among the most debilitating outcomes of stroke. Aphasia is a language disorder occurring in 10-30% of stroke survivors. Speech and Language Therapy (SLT) is the gold standard, mainstay treatment for aphasia, but gains from SLT may be incomplete. Pharmaceutical and noninvasive brain stimulation (NIBS) techniques may augment the effectiveness of SLT. Areas covered: Herein reviewed are studies of the safety and efficacy of these adjunctive interventions for aphasia, including randomized placebo-controlled and open-label trials, as well as case series from Pubmed, using search terms 'pharmacological,' 'tDCS' or 'TMS' combined with 'aphasia' and 'stroke.' Expert commentary: Relatively small studies have included participants with a range of aphasia types and severities, using inconsistent interventions and outcome measures. Results to-date have provided promising, but weak to moderate evidence that medications and/or NIBS can augment the effects of SLT for improving language outcomes. We end with recommendations for future approaches to studying these interventions, with multicenter, double-blind, randomized controlled trials.
失语症是中风最致残的后果之一。失语症是一种语言障碍，发生在 10-30%的中风幸存者中。言语和语言治疗（SLT）是失语症的金标准、主要治疗方法，但 SLT 的效果可能不完整。药物和非侵入性脑刺激（NIBS）技术可能增强 SLT 的效果。涵盖领域：本文综述了这些辅助干预措施治疗失语症的安全性和有效性研究，包括随机安慰剂对照和开放标签试验，以及来自 Pubmed 的病例系列，使用的搜索词是“药理学”、“tDCS”或“TMS”与“失语症”和“中风”相结合。专家评论：相对较小的研究包括了各种类型和严重程度的失语症参与者，使用了不一致的干预措施和结果测量方法。迄今为止的结果提供了有希望但较弱到中等强度的证据，表明药物和/或 NIBS 可以增强 SLT 改善语言结果的效果。我们以对这些干预措施进行多中心、双盲、随机对照试验的未来方法建议作为结束。
