Nooriani Narjes, Saeedirad Zahra, Shekari Soheila, Nami Sheyda, Mahmoudi Zahra, Abbasi Mobarakeh Khadijeh, Adabi Somayyeh Bararnia, Khodarahmi Shiva, Bahmani Parsa, Doaei Saeid, Ajami Marjan, Gholamalizadeh Maryam
Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Nutr. 2024 Dec 20;11:1428648. doi: 10.3389/fnut.2024.1428648. eCollection 2024.
BACKGROUND: Spontaneous abortion (SA) is reported to be associated with Fat Mass And Obesity-Associated FTO genotype and dietary intake of selenium. This research assessed the potential interactions between the risk of SA, dietary selenium intake, and the FTO rs9939609 polymorphism. METHODS: This case-control study encompassed 192 women who experienced SA and 347 control participants. Dietary selenium intake was evaluated using a comprehensive food frequency questionnaire (FFQ) and Nutritionist IV software. The FTO gene was genotyped for rs9939609 polymorphism. RESULT: The findings showed that there were no significant variations in the case and control groups' dietary selenium intake. A lower selenium intake was inversely associated with SA only among individuals with the TT genotype of the FTO gene ( = -0.19, = 0.04). The results remained unchanged when age, BMI, physical activity, smoking, alcohol consumption, and calorie intake were taken into account. CONCLUSION: A link may exist between selenium consumption and SA, especially in individuals with the TT genotype in the FTO gene. These findings underline the influence of genetic factors on how dietary intake impacts SA. Further investigation is required to validate these conclusions.
背景：据报道，自然流产（SA）与脂肪量和肥胖相关基因FTO基因型以及硒的饮食摄入量有关。本研究评估了SA风险、饮食硒摄入量和FTO rs9939609多态性之间的潜在相互作用。 方法：本病例对照研究纳入了192名经历过SA的女性和347名对照参与者。使用综合食物频率问卷（FFQ）和Nutritionist IV软件评估饮食硒摄入量。对FTO基因进行rs9939609多态性基因分型。 结果：研究结果表明，病例组和对照组的饮食硒摄入量没有显著差异。仅在FTO基因TT基因型个体中，较低的硒摄入量与SA呈负相关（β=-0.19，P=0.04）。在考虑年龄、体重指数、身体活动、吸烟、饮酒和卡路里摄入量后，结果保持不变。 结论：硒摄入量与SA之间可能存在联系，尤其是在FTO基因TT基因型个体中。这些发现强调了遗传因素对饮食摄入量如何影响SA的作用。需要进一步研究来验证这些结论。
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