Bannon Shelley, Gonsalvez Craig J, Croft Rodney J, Boyce Philip M
Department of Psychology, University of Wollongong, Australia.
Psychiatry Res. 2002 Jun 1;110(2):165-74. doi: 10.1016/s0165-1781(02)00104-x.
Difficulty inhibiting irrelevant information may play a central role in the aetiology of obsessive-compulsive disorder (OCD). The aim of the present study was to determine whether OCD subjects (n=20) exhibit deficits in behavioural and cognitive inhibition compared with a clinical control group diagnosed with panic disorder (n=20). All subjects were administered a Go/Nogo task (a measure of behavioural inhibition) and a Stroop test (a measure of cognitive inhibition). OCD subjects made more commission errors on the Go/Nogo task, and they made more errors and displayed longer reaction times on the interference trial of the Stroop task. Trends towards correlations were observed between OCD severity scores and Stroop reaction time, where the more severe the OCD symptoms the faster was the response. No correlations between clinical symptomatology or subject demographics and the Go/Nogo task were observed. It was demonstrated that OCD subjects exhibit deficits in behavioural and cognitive inhibition, which together may underlie the repetitive symptomatic behaviours of the disorder, such as compulsions and obsessions.
难以抑制无关信息可能在强迫症（OCD）的病因中起核心作用。本研究的目的是确定强迫症患者（n = 20）与诊断为惊恐障碍的临床对照组（n = 20）相比，在行为和认知抑制方面是否存在缺陷。所有受试者都接受了一项“停止信号任务”（一种行为抑制测量）和一项斯特鲁普测验（一种认知抑制测量）。强迫症患者在“停止信号任务”中出现更多的错误反应，并且在斯特鲁普任务的干扰试验中出现更多错误且反应时间更长。观察到强迫症严重程度评分与斯特鲁普反应时间之间存在相关趋势，即强迫症症状越严重，反应越快。未观察到临床症状或受试者人口统计学特征与“停止信号任务”之间存在相关性。结果表明，强迫症患者在行为和认知抑制方面存在缺陷，这可能共同构成了该疾病重复性症状行为（如强迫行为和强迫观念）的基础。
