通过长期输注胰岛素使人类糖尿病患者空腹高胰高血糖素血症及对静脉注射精氨酸的过度胰高血糖素反应正常化。
Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin.
作者信息
Gerich J E, Tsalikian E, Lorenzi M, Schneider V, Bohannon N V, Gustafson G, Karam J H
出版信息
J Clin Endocrinol Metab. 1975 Dec;41(06):1178-80. doi: 10.1210/jcem-41-6-1178.
PMID:1206104
Abstract
Infusion of insulin (1 U/hr) for 14 hr suppressed basal glucagon levels and normalized previously excessive glucagon responses to arginine in juvenile-onset, insulin-dependent diabetic subjects, indicating that abnormal pancreatic alpha-cell function in human juvenile-onset diabetes mellitus may be a consequence of insulin lack.
摘要
对青少年起病的胰岛素依赖型糖尿病患者输注胰岛素（1单位/小时），持续14小时，可抑制基础胰高血糖素水平，并使先前对精氨酸过度的胰高血糖素反应恢复正常，这表明人类青少年起病的糖尿病中胰腺α细胞功能异常可能是胰岛素缺乏的结果。
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