祁连圆柏中的萜类化合物及其抗肿瘤活性。
Terpenes from Juniperus przewalskii and their antitumor activities.
作者信息
Wang Wen-Shu, Li Er-Wei, Jia Zhong-Jian
机构信息
Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China.
出版信息
Pharmazie. 2002 May;57(5):343-5.
PMID:12061261
Abstract
Two new diterpenes were isolated from Juniperus przewalskii, together with 17 known terpense. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2DNMR). In addition, 3 alpha-hinokiol (3) and 3 alpha-hydroxymannol (9) exhibited effective antitumor activities to cervical carcinoma (HeLa) and human ovarian carcinoma (HO-8910) cell lines.
摘要
从祁连圆柏中分离出两种新的二萜类化合物，以及17种已知的萜类化合物。通过光谱方法（红外光谱、质谱、1H、13C和二维核磁共振）对它们的结构进行了阐明。此外，3α-扁柏酚（3）和3α-羟基甘露醇（9）对子宫颈癌（HeLa）和人卵巢癌（HO-8910）细胞系表现出有效的抗肿瘤活性。
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