Wang Xiu-Ran, Wu Quan-Xiang, Shi Yan-Ping
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Chem Biodivers. 2008 Feb;5(2):279-89. doi: 10.1002/cbdv.200890025.
A total of 27 natural products were isolated from Saussurea cauloptera, including two new eudesmane-type sesquiterpenoids, the gerin derivatives 2 and 3, and one new ent-labdane diterpenoid, compound 9. The known compounds included six sesquiterpenoids, eleven triterpenoids, six sterols, and one lignan. Their structures were elucidated on the basis of extensive spectroscopic and mass-spectrometric analyses, as well as by X-ray crystallography in the case of gerin (1). The structurally related compounds 1-4 were found to exhibit strong inhibitory activities against human gastric carcinoma (SGC-7901) cells.
从翼茎风毛菊中总共分离出27种天然产物，包括两种新的桉叶烷型倍半萜类化合物，即吉任衍生物2和3，以及一种新的对映-贝壳杉烷二萜类化合物，化合物9。已知化合物包括六种倍半萜类化合物、十一种三萜类化合物、六种甾醇和一种木脂素。它们的结构是在广泛的光谱和质谱分析的基础上阐明的，对于吉任（1），还通过X射线晶体学进行了阐明。发现结构相关的化合物1-4对人胃癌（SGC-7901）细胞表现出强烈的抑制活性。
