来自加氏安维尔菊的抗肿瘤吉马烷型倍半萜内酯

Antitumor germacranolides from Anvillea garcinii.

作者信息

Abdel Sattar E, Galal A M, Mossa G S

机构信息

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh Saudi Arabia.

出版信息

J Nat Prod. 1996 Apr;59(4):403-5. doi: 10.1021/np960064g.

DOI:10.1021/np960064g

PMID:8699183

Abstract

The aerial parts of Anvillea garcinii yielded two new germacranolides, 9 alpha-hydroxy-1 beta, 10 alpha-epoxyparthenolide (4) and parthenolid-9-one (5), in addition to the known 9 alpha-hydroxyparthenolide (1), 9 beta-hydroxyparthenolide (2), and 9 beta-hydroxy-1 beta, 10 alpha-epoxyparthenolide (3). The structures of the new compounds were elucidated from their spectral data (IR, MS, 1H- and 13C-NMR, 1H-1H COSY, and 1H-13C HETCOR) and by chemical derivatization. The hitherto unreported 13C-NMR data and carbon atom assignments of the previously isolated lactones 1, 2, and 3 were given. The in-vitro antitumor and anti-HIV activities were evaluated for the isolated compounds.

摘要

除了已知的9α-羟基小白菊内酯（1）、9β-羟基小白菊内酯（2）和9β-羟基-1β,10α-环氧小白菊内酯（3）外，加氏安维尔草的地上部分还产生了两种新的吉马烷型倍半萜内酯，9α-羟基-1β,10α-环氧小白菊内酯（4）和小白菊内酯-9-酮（5）。通过光谱数据（红外光谱、质谱、1H-和13C-核磁共振、1H-1H化学位移相关谱和1H-13C异核多量子相干谱）以及化学衍生化对新化合物的结构进行了阐明。给出了先前分离得到的内酯1、2和3尚未报道的13C-核磁共振数据和碳原子归属。对分离得到的化合物进行了体外抗肿瘤和抗HIV活性评估。