Prunier Fabrice, Gaertner Roger, Louedec Liliane, Michel Jean-Baptiste, Mercadier Jean-Jacques, Escoubet Brigitte
Institut National de la Santé et de la Recherche Médicale Unité 460, Faculté de Médecine Xavier Bichat, Paris, France.
Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H346-52. doi: 10.1152/ajpheart.01050.2001.
The spectral Doppler mitral flow pattern, alone or combined with tissue Doppler mitral annulus velocity, can be used to predict left ventricular (LV) filling pressure in humans, whereas invasive hemodynamic measurements are still required in the rat. This study was undertaken to assess whether LV end-diastolic pressure (LVEDP) can be estimated using Doppler echocardiography in the rat after myocardial infarction (MI). Thirty-seven rats (23 rats with MI after left coronary artery ligation and 14 sham-operated rats) were evaluated 3 mo after surgery with echo-Doppler and invasive hemodynamic measurements. Pulse wave spectral Doppler at the mitral valve tip was used to measure the E wave, the E wave deceleration time (DT), and the A wave; spectral Doppler tissue imaging was used to measure the early diastolic lateral mitral annulus velocity (E(a)). We found weak correlations between LVEDP and the peak velocity of the early mitral inflow (E), E/peak velocity of the late mitral inflow, and DT, and strong correlations with E(a) and especially with E/E(a) [R(2) = 0.89, LVEDP (in mmHg) = 0.987E/E(a) - 4.229]. Longitudinal followup of a subgroup of rats with MI revealed a marked rise of E/E(a) between days 7 and 21 in rats with heart failure only. We conclude that Doppler echocardiography can be used for serial assessment of LV diastolic function in rats with MI.
频谱多普勒二尖瓣血流模式，单独使用或与组织多普勒二尖瓣环速度相结合，可用于预测人类的左心室（LV）充盈压，而在大鼠中仍需要进行有创血流动力学测量。本研究旨在评估心肌梗死（MI）后大鼠是否可以使用多普勒超声心动图估计左心室舒张末期压力（LVEDP）。37只大鼠（23只左冠状动脉结扎后发生MI的大鼠和14只假手术大鼠）在手术后3个月接受了回声多普勒和有创血流动力学测量评估。使用二尖瓣尖处的脉冲波频谱多普勒测量E波、E波减速时间（DT）和A波；使用频谱多普勒组织成像测量舒张早期二尖瓣环侧壁速度（E(a)）。我们发现LVEDP与二尖瓣早期流入峰值速度（E）、二尖瓣晚期流入峰值速度的E/比值以及DT之间存在弱相关性，与E(a)尤其是E/E(a)存在强相关性[R(2)=0.89，LVEDP（以mmHg为单位）=0.987E/E(a)-4.229]。对MI大鼠亚组的纵向随访显示，仅在心力衰竭大鼠中，E/E(a)在第7天至第21天之间显著升高。我们得出结论，多普勒超声心动图可用于对MI大鼠的左心室舒张功能进行连续评估。
