Xin Juan-Juan, Gao Jun-Hong, Wang Yuan-Yuan, Lu Feng-Yan, Zhao Yu-Xue, Jing Xiang-Hong, Yu Xiao-Chun
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China.
Evid Based Complement Alternat Med. 2017;2017:9708094. doi: 10.1155/2017/9708094. Epub 2017 Feb 15.
The aim of this work is to investigate the effect of electroacupuncture (EA) at PC6 on the hypertension and myocardial hypertrophy in spontaneously hypertensive rats (SHRs). Thirty SHRs were randomized into model, SHR + EA, and SHR + Sham EA group with WKY rats as normal control. EA was applied once a day in 8 consecutive weeks. The blood pressure (BP), cardiac function, and hypertrophy as well as the underlying mechanisms were investigated. After EA treatment, the enhanced BP in SHR + EA group was significantly lower compared to both the period before EA and model group. Echocardiographic, morphological studies showed that the enhanced left ventricular anterior and posterior wall end-diastolic (LVAWd and LVPWd) thickness, diameters and cross-sectional area (CSA) of cardiac myocyte, as well as the ratio of heart weight to body weight (HW/BW), were markedly diminished in SHR + EA group, while the reduced left ventricular ejection fraction, left ventricular short axis fraction shortening, and E/A ratio were significantly ameliorated. The levels of Angiotensin-converting enzyme (ACE) and Angiotensin II Type 1 and 2 receptors (AT1R, AT2R) in SHRs were also significantly attenuated by EA. The results suggest that EA at bilateral PC6 could arrest the hypertension development and ameliorate the cardiac hypertrophy and malfunction in SHRs, which might be mediated by the regulation of ACE, AT1R, and AT2R.
本研究旨在探讨针刺内关穴对自发性高血压大鼠（SHR）高血压及心肌肥厚的影响。将30只SHR随机分为模型组、SHR+电针组和SHR+假电针组，以WKY大鼠作为正常对照组。连续8周每天进行一次电针治疗。观察血压（BP）、心功能、心肌肥厚情况及其潜在机制。电针治疗后，SHR+电针组升高的血压与电针治疗前及模型组相比均显著降低。超声心动图和形态学研究表明，SHR+电针组左心室前壁和后壁舒张末期厚度（LVAWd和LVPWd）、心肌细胞直径和横截面积（CSA）以及心脏重量与体重之比（HW/BW）均显著减小，而降低的左心室射血分数、左心室短轴缩短率和E/A比值均得到显著改善。电针还显著降低了SHR中血管紧张素转换酶（ACE）及血管紧张素II 1型和2型受体（AT1R、AT2R）的水平。结果表明，双侧内关穴电针可抑制SHR高血压的发展，改善心肌肥厚和功能障碍，其机制可能与调节ACE、AT1R和AT2R有关。
