Hancock Barry W, Tidy John A
Trophoblastic Disease Centre, Weston Park Hospital/University of Sheffield, Sheffield, U.K.
J Reprod Med. 2002 May;47(5):347-54.
Molar pregnancy remains an uncommon and still not fully understood disorder. The clinical presentation has changed over recent decades. In developed countries complete moles are now usually diagnosed early (on clinical and/or ultrasound scan criteria) so that the more severe clinical presentations are much less commonly seen. The important differences between complete and partial moles and their risk factors are now well recognized. Common protocols for managing persistent gestational trophoblastic disease are being derived, and molecular genetic studies are advancing our understanding of molar pregnancy and its sequelae. Cure rates approaching 100% should now be the rule rather than the exception. There is a strong case for formal registration and monitoring of all cases through specialist centers.
葡萄胎仍然是一种罕见且尚未被完全理解的疾病。近几十年来，其临床表现发生了变化。在发达国家，完全性葡萄胎现在通常能早期诊断（依据临床和/或超声扫描标准），因此更严重的临床表现已较少见。完全性和部分性葡萄胎之间的重要差异及其危险因素现已得到充分认识。针对持续性妊娠滋养细胞疾病的常见管理方案正在形成，分子遗传学研究也在增进我们对葡萄胎及其后遗症的理解。如今治愈率接近100%应成为常规而非例外情况。通过专业中心对所有病例进行正式登记和监测很有必要。
