Riadh Ben Temime, Abdellatif Chechia, Wissal Hannachi, Leila Attia, Taher Makhlouf, Abdelhamid Koubaa
Department of obstetrics and gynecology, Charles Nicolle University Hospital Tunis, Tunisia.
Int J Biomed Sci. 2009 Dec;5(4):321-5.
The aim of the study was to identify the incidence, diagnosis, therapeutic and histological particularities of molar pregnancies and to evaluate our management of gestational trophoblastic tumors (GTT) according to the recommendations of FIGO.
This was a retrospective study of 90 patients who were diagnosed with molar pregnancy from January 1991 to December 2007. After remission, post molar pregnancy surveillance was continued for one year. Patients whose condition required chemotherapy for GTT were attributed a FIGO/WHO score.
Molar pregnancy occurred in 90 women. The frequency of molar pregnancy was 1 per 1124 pregnancies. The mean age was 32.21 years. Molar pregnancies were more frequent in pauciparous patients (52.24%). At diagnosis, the median gestational age was 13 weeks. The main presenting symptom was metrorrhagia (90%). Treatment consisted in uterine evacuation by suction curettage. Histological findings were complete mole in 66.66% of the cases and partial mole in 33.33% of the cases. 81 patients (90%) achieved remission without chemotherapy and 9 patients (10%) had FIGO stage I GTT. They achieved remission with a monochemotherapy.
The practice of ultrasonography in the first trimester of pregnancy allows an early diagnosis of molar pregnancy and an adequate treatment and follow-up.
本研究旨在确定葡萄胎妊娠的发病率、诊断、治疗及组织学特征，并根据国际妇产科联盟（FIGO）的建议评估我们对妊娠滋养细胞肿瘤（GTT）的管理。
这是一项对1991年1月至2007年12月期间诊断为葡萄胎妊娠的90例患者的回顾性研究。缓解后，葡萄胎妊娠后的监测持续一年。因GTT需要化疗的患者被赋予FIGO/WHO评分。
90名女性发生葡萄胎妊娠。葡萄胎妊娠的发生率为每1124次妊娠中有1例。平均年龄为32.21岁。葡萄胎妊娠在初产妇中更常见（52.24%）。诊断时，中位孕周为13周。主要症状是子宫出血（90%）。治疗方法是通过吸刮术清空子宫。组织学检查结果显示，66.66%的病例为完全性葡萄胎，33.33%的病例为部分性葡萄胎。81例患者（90%）未经化疗即缓解，9例患者（10%）为FIGO I期GTT。他们通过单一化疗实现了缓解。
在妊娠早期进行超声检查可实现葡萄胎妊娠的早期诊断以及适当的治疗和随访。
