新型耐环丙沙星、对萘啶酸敏感的金黄色葡萄球菌突变体
Novel ciprofloxacin-resistant, nalidixic acid-susceptible mutant of Staphylococcus aureus.
作者信息
Piddock Laura J V, Jin Yu Fang, Webber Mark A, Everett Martin J
机构信息
Antimicrobial Agents Research Group, Division of Immunity & Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2002 Jul;46(7):2276-8. doi: 10.1128/AAC.46.7.2276-2278.2002.
Abstract
A ciprofloxacin-resistant, nalidixic acid-susceptible mutant of Staphylococcus aureus (F145) contained no mutations within gyrA, gyrB, grlA, and grlB or within norA or its promoter region. MICs and accumulation studies suggest the role of a novel multidrug efflux pump.
摘要
一株对环丙沙星耐药、对萘啶酸敏感的金黄色葡萄球菌突变株（F145）在gyrA、gyrB、grlA和grlB基因内以及norA基因或其启动子区域均未发生突变。最低抑菌浓度（MIC）和蓄积研究提示存在一种新型多药外排泵的作用。
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