Anstey A V
Photodermatology Unit, Department of Dermatology, University of Wales College of Medicine, Cardiff, UK.
Clin Exp Dermatol. 2002 May;27(3):170-6. doi: 10.1046/j.1365-2230.2002.01040.x.
Cutaneous photodamage is partly mediated via oxidative pathways and there is evidence to suggest that antioxidants within the skin may have a photoprotective effect. Antioxidant activity is provided by a number of naturally occurring substances including alpha-tocopherol (vitamin E) and beta-carotene, whose effects are mediated by their capacity to quench singlet oxygen, scavenge free radicals and prevent the formation of free radicals. Beta-carotene has been used as treatment for various photosensitivity disorders for more than 30 years. The main indication for its use is in the treatment of the photosensitivity associated with erythropoietic protoporphyria. A role for beta-carotene in the prevention of non-melanoma skin cancer has yet to be demonstrated despite clinical research activity in this area. The role for alpha-tocopherol as a photoprotective agent is less clear-cut and it has yet to be established as treatment either for conditions characterized by photosensitivity or as an agent for preventing chronic photodamage or cutaneous malignancy.
皮肤光损伤部分通过氧化途径介导，有证据表明皮肤内的抗氧化剂可能具有光保护作用。多种天然物质具有抗氧化活性，包括α-生育酚（维生素E）和β-胡萝卜素，它们的作用是通过淬灭单线态氧、清除自由基和防止自由基形成来介导的。β-胡萝卜素已用于治疗各种光敏性疾病30多年。其主要适应证是治疗与红细胞生成性原卟啉症相关的光敏性。尽管该领域有临床研究活动，但β-胡萝卜素在预防非黑素瘤皮肤癌中的作用尚未得到证实。α-生育酚作为光保护剂的作用尚不清楚，它尚未被确立为治疗光敏性疾病的药物，也未被确立为预防慢性光损伤或皮肤恶性肿瘤的药物。
