Mehta R K, Mallett R B, Green C, Rytina E
Department of Dermatology, Addenbrooke's Hospital, Oxford, UK.
Clin Exp Dermatol. 2002 May;27(3):216-9. doi: 10.1046/j.1365-2230.2002.01016.x.
We describe two patients with palmar filiform hyperkeratosis, characterized by multiple thin spiny keratotic projections on the palms. The condition has been associated with an underlying malignancy in some cases. One patient has myelofibrosis, an association not previously described. In addition we describe a further patient with filiform hyperkeratoses of both palms and soles with no associated underlying disorder. In view of the relatively high risk of underlying malignancy occurring in patients with filiform hyperkeratosis, these patients should always be investigated fully.
我们描述了两名患有掌部丝状角化过度症的患者，其特征为手掌上有多个细小的棘状角化性突起。在某些情况下，这种病症与潜在的恶性肿瘤有关。一名患者患有骨髓纤维化，这是一种此前未被描述过的关联。此外，我们还描述了另一名双手掌和双足底均有丝状角化过度症且无相关潜在疾病的患者。鉴于丝状角化过度症患者发生潜在恶性肿瘤的风险相对较高，这些患者应始终接受全面检查。
