Johnson O, Hernell O, Olivecrona T
Lipids. 1975 Dec;10(12):765-9. doi: 10.1007/BF02532318.
The effect of 3 different single doses of ethanol on the liver triacylglycerol concentration and on the metabolism of intravenously injected 14C-oleic acid in fasted rats was studied. All 3 doses (2, 3.75, and 6 g ethanol/kg body wt) caused a rapid increase in the liver triacylglycerol concentration during the first 5-6 hr after the ethanol was given. Until the plasma ethanol concentration had fallen to low values, the high liver triacylglycerol levels were raised and were independent of the ethanol dose given. The incorporation of radioactivity from intravenously injected 14C-oleic acid into liver triacylglycerols was increased over control values to the same extent in all rats given ethanol as long as the plasma ethanol concentration was above a low level. High rates of ethanol oxidation and increased utilization of plasma free fatty acids for liver triacylglycerol synthesis were closely correlated with the development and maintenance of the ethanol induced liver triacylglycerol accumulation.
研究了3种不同单剂量乙醇对禁食大鼠肝脏三酰甘油浓度以及静脉注射14C-油酸代谢的影响。所有3个剂量（2、3.75和6 g乙醇/千克体重）在给予乙醇后的最初5 - 6小时内均导致肝脏三酰甘油浓度迅速升高。在血浆乙醇浓度降至低值之前，肝脏三酰甘油的高水平一直维持，且与给予的乙醇剂量无关。只要血浆乙醇浓度高于低水平，在所有给予乙醇的大鼠中，静脉注射14C-油酸的放射性掺入肝脏三酰甘油的量均比对照值增加相同程度。乙醇的高氧化率以及血浆游离脂肪酸用于肝脏三酰甘油合成的利用率增加与乙醇诱导的肝脏三酰甘油积累的发生和维持密切相关。
