急性乙醇喂养和慢性苯氟雷司给药对大鼠肝脏和脂肪组织中甘油脂质合成的某些酶活性的影响。
The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue.
作者信息
Pritchard P H, Bowley M, Burditt S L, Cooling J, Glenny H P, Lawson N, Sturton R G, Brindley D N
出版信息
Biochem J. 1977 Sep 15;166(3):639-42. doi: 10.1042/bj1660639.
Abstract
Rats were treated for 5 days with benfluorex [1-(3-trifluoromethylphenyl)-2-[N-(2-benzoyloxyethyl)amino]propane] or with suspending medium (controls). They were then intubated with an acute intoxicating dose of ethanol or with glucose of equivalent energy content. Treatment of the control rats with ethanol specifically increases the hepatic activity of the soluble phosphatidate phosphohydrolase by about 5-fold in 6 h. The equivalent increase for the benfluorex-treated rats were about 2-fold. The results are discussed in relation to the effects of ethanol and benfluorex on glycerolipid synthesis.
摘要
用苯氟雷司[1-(3-三氟甲基苯基)-2-[N-(2-苯甲酰氧基乙基)氨基]丙烷]或悬浮介质（对照组）对大鼠进行5天的治疗。然后给它们插管注入急性中毒剂量的乙醇或能量含量相当的葡萄糖。用乙醇处理对照组大鼠会使可溶性磷脂酸磷酸水解酶的肝脏活性在6小时内特异性增加约5倍。苯氟雷司处理组大鼠的相应增加约为2倍。结合乙醇和苯氟雷司对甘油脂质合成的影响对结果进行了讨论。
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The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue.急性乙醇喂养和慢性苯氟雷司给药对大鼠肝脏和脂肪组织中甘油脂质合成的某些酶活性的影响。
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