Nociti Francisco Humberto, César Neto João Batista, Carvalho Marcelo Diniz, Sallum Enilson Antonio
Department of Prosthodontics and Periodontics, School of Dentistry at Piracicaba, São Paulo, Brazil.
Int J Oral Maxillofac Implants. 2002 May-Jun;17(3):347-52.
This study investigated the influence of cigarette smoke on bone healing around titanium implants placed in rats.
After administration of anesthesia, the tibia surface was exposed and screw-shaped titanium implants (4.0 mm in length and 2.2 mm in diameter) were placed bilaterally (1 each side). The animals (n = 32) were randomly assigned to either group 1 (control, n = 18) or group 2 (intermittent cigarette smoke inhalation, n = 14). After 60 days, the animals were sacrificed and undecalcified sections obtained. Bone density (the proportion of mineralized bone in a 500-microm-wide zone lateral to the implant) was measured in the cortical (zone A) and cancellous bone (zone B) areas.
In zone A, a slight difference in bone density was noted between the groups (96.18% +/- 1.08% and 95.38 +/- 1.17% in groups 1 and 2, respectively; P > .05) but was not statistically significant. In contrast, bone density was significantly decreased in zone B in the animals that were exposed to cigarette smoke (17.57 +/- 6.45% and 11.30 +/- 6.81% for groups 1 and 2, respectively; P < .05).
Whether different results would be observed if animals were exposed to cigarette smoke for a longer period of time and/or before implant placement remains to be investigated.
Although intermittent cigarette smoke exposure may not seriously affect cortical bone density, it may jeopardize bone quality around titanium implants in the cancellous bone area.
本研究调查香烟烟雾对大鼠体内钛植入物周围骨愈合的影响。
麻醉给药后，暴露胫骨表面，双侧植入螺旋形钛植入物（长度4.0毫米，直径2.2毫米）（每侧1个）。将动物（n = 32）随机分为1组（对照组，n = 18）或2组（间歇性吸入香烟烟雾组，n = 14）。60天后，处死动物并获取不脱钙切片。在皮质骨（A区）和松质骨（B区）测量骨密度（植入物侧面500微米宽区域内矿化骨的比例）。
在A区，两组之间骨密度存在轻微差异（1组和2组分别为96.18%±1.08%和95.38±1.17%；P>.05），但无统计学意义。相比之下，暴露于香烟烟雾的动物B区骨密度显著降低（1组和2组分别为17.57±6.45%和11.30±6.81%；P<.05）。
如果动物在更长时间和/或植入前暴露于香烟烟雾中是否会观察到不同结果仍有待研究。
虽然间歇性暴露于香烟烟雾可能不会严重影响皮质骨密度，但可能会损害松质骨区域钛植入物周围的骨质量。
