Department of Anatomy, University of José Rosário Vellano (UNIFENAS), Alfenas, MG, Brazil.
J Bone Miner Metab. 2010;28(1):101-7. doi: 10.1007/s00774-009-0115-1. Epub 2009 Aug 8.
The consumption of alcohol or nicotine is harmful to the integrity of bone tissue, hindering or even impeding the fixation and maintenance of bone implants. The aim of the present work was to evaluate the effects of ethanol and nicotine, when consumed alone and simultaneously, on both bone mechanical resistance and bone neoformation around hydroxyapatite implants. Twenty rats were divided into four groups: control (CT), alcohol (A), nicotine (N) and nicotine + alcohol (N + A). After 4 weeks of alcohol and/or nicotine consumption, dense (HAD) and porous (HAP) bodies were respectively implanted in a surgically produced bone defect in the right and left tibiae. After the surgeries, the animals continued to consume alcohol and/or nicotine. After ninety days, the animals were sacrificed and the tibiae and femurs were isolated for histological processing and mechanical assays. All the animals presented newly formed bone tissue close to the HAD and HAP ceramic bodies. The animals of the N + A group presented a smaller volume of neoformed bone. Group A animals presented smaller bone volume around the implants in relation to the animals from group N. Bone resistance to mechanical loads was smallest in animals from the N + A group, followed (in order) by the A and N groups. Thus, it can be concluded that nicotine or alcohol consumption produced negative effects on bone mechanical resistance and on the osteogenesis around the HAD and HAP implants. In addition, the simultaneous consumption of the two substances intensified their harmful effects.
饮酒或吸烟会损害骨组织的完整性，阻碍甚至破坏骨植入物的固定和维持。本研究旨在评估单独和同时摄入乙醇和尼古丁对羟磷灰石植入物周围骨机械阻力和新骨形成的影响。20 只大鼠分为 4 组：对照组（CT）、酒精组（A）、尼古丁组（N）和尼古丁+酒精组（N+A）。在 4 周的酒精和/或尼古丁摄入后，分别将致密（HAD）和多孔（HAP）体植入右侧和左侧胫骨的手术产生的骨缺损中。手术后，动物继续摄入酒精和/或尼古丁。90 天后，处死动物，分离胫骨和股骨进行组织学处理和力学测定。所有动物均在 HAD 和 HAP 陶瓷体附近形成了新的骨组织。N+A 组动物的新骨形成体积较小。与 N 组动物相比，A 组动物的植入物周围骨体积较小。N+A 组动物的骨对机械负荷的抵抗力最小，其次是 A 组和 N 组。因此，可以得出结论，尼古丁或酒精的摄入对 HAD 和 HAP 植入物周围骨的机械阻力和骨生成产生了负面影响。此外，同时摄入两种物质会加剧其有害影响。
