Bueno L, Fioramonti J
Department of Neurogastroenterology and Nutrition, Institut National de la Recherche Agronomique, Neurogastroenterology Unit INRA, 180 Chemin de Tournefeville, BP3 31931 Toulouse Cedex 9, France.
Gut. 2002 Jul;51 Suppl 1(Suppl 1):i19-23. doi: 10.1136/gut.51.suppl_1.i19.
Visceral hypersensitivity is currently the most widely accepted mechanism responsible for abdominal pain. Inflammatory mediators are known to sensitise primary afferents and to recruit silent nociceptors. Recent evidence suggests that non-inflammatory mediators also have the potential to trigger visceral pain. This sequence of events may constitute part of an alerting system which prompts the central nervous system to correct gastrointestinal responses to ingestion.
内脏高敏感性是目前被广泛接受的导致腹痛的机制。已知炎症介质可使初级传入神经敏感化并募集沉默的伤害感受器。最近的证据表明,非炎症介质也有可能引发内脏疼痛。这一系列事件可能构成警报系统的一部分,该系统促使中枢神经系统纠正胃肠道对摄入物的反应。