Bradesi S, Eutamene H, Theodorou V, Fioramonti J, Bueno L
Institut National de la Recherche Agronomique, Dept of Neurogastroenterology & Nutrition, Toulouse, France.
Life Sci. 2001 Jan 19;68(9):1047-56. doi: 10.1016/s0024-3205(00)01008-0.
Evidence exists to support the concept that ovarian hormones influence mast cell functioning and related events. Here, we evaluated the constitutive gender difference and the influence of ovarian status on rat mast cell (MC) distribution in jejunum and colon, histamine synthesis and/or its release elicited by Substance P (SP). Higher mast cell (MC) number and histamine release were found in female compared with male. In female rats, hormonal status did not affect the density of resident MC neither in the jejunum nor in the colon. Interestingly, histamine levels released after SP stimulation of jejunal segment was reduced in ovariectomized (OVX) compared with sham OVX rats, and restored in OVX female receiving progesterone. In the colon, OVX resulted in a significant increase in histamine levels released after SP stimulation and a treatment with progesterone did not restore basal histamine levels. Thus, ovarian steroid hormones do not affect jejunal and colonic mast cell number. However, the hormonal status differently influences jejunal and colonic MC sensitivity to SP.
有证据支持卵巢激素影响肥大细胞功能及相关事件这一概念。在此，我们评估了大鼠空肠和结肠中肥大细胞（MC）分布的固有性别差异以及卵巢状态的影响，物质P（SP）引发的组胺合成和/或释放情况。与雄性相比，雌性大鼠的肥大细胞（MC）数量更多且组胺释放量更高。在雌性大鼠中，激素状态对空肠和结肠中常驻MC的密度均无影响。有趣的是，与假手术切除卵巢（sham OVX）的大鼠相比，切除卵巢（OVX）的大鼠空肠段经SP刺激后释放的组胺水平降低，而接受孕酮的OVX雌性大鼠中组胺水平恢复。在结肠中，OVX导致SP刺激后释放的组胺水平显著升高，孕酮治疗并未恢复基础组胺水平。因此，卵巢甾体激素不影响空肠和结肠肥大细胞数量。然而，激素状态对空肠和结肠MC对SP的敏感性有不同影响。
