Stickel F, Schuppan D, Hahn E G, Seitz H K
Department of Medicine I, Division of Hepatology, University of Erlangen-Nuremberg, Germany.
Gut. 2002 Jul;51(1):132-9. doi: 10.1136/gut.51.1.132.
Alcohol is a major aetiological factor in hepatocarcinogenesis but our understanding of its importance as a modulating factor is just beginning to emerge. In the present review, a number of possible cofactors and mechanisms are discussed by which alcohol may enhance the development of hepatoma. These include dietary or environmental carcinogens ingested along with alcoholic beverages, alcoholic cirrhosis as a precancerous condition, and the effects of alcohol metabolism.
酒精是肝癌发生的主要病因,但我们对其作为调节因子的重要性的认识才刚刚开始显现。在本综述中,讨论了酒精可能促进肝癌发生的一些潜在辅助因素和机制。这些因素包括与酒精饮料一起摄入的饮食或环境致癌物、作为癌前病变的酒精性肝硬化以及酒精代谢的影响。