Bonvento Gilles, Sibson Nicola, Pellerin Luc
CEA CNRS URA 2210, Service Hospitalier Frédéric Joliot 4, place du Général Leclerc, 91401 Orsay Cedex, France.
Trends Neurosci. 2002 Jul;25(7):359-64. doi: 10.1016/s0166-2236(02)02168-9.
Functional imaging methods exploit the relationship between neuronal activity, energy demand and cerebral blood flow to functionally map the brain. Despite the increasing use of these imaging tools in basic and clinical neuroscience, the neurobiological processes underlying the imaging signals remain unclear. Recently, interest has been focused on uncovering the signals that trigger the metabolic and vascular changes accompanying variations in neuronal activity. Advances in this field have demonstrated that release of the major excitatory neurotransmitter glutamate initiates diverse signaling processes between neurons and astrocytes, and that this signaling could be crucial for the occurrence of brain imaging signals. In this article we review the hypothesis that glutamate represents a common trigger for both neurometabolic and neurovascular coupling.
功能成像方法利用神经元活动、能量需求和脑血流量之间的关系对大脑进行功能图谱绘制。尽管这些成像工具在基础和临床神经科学中的应用日益广泛，但成像信号背后的神经生物学过程仍不清楚。最近，人们的兴趣集中在揭示触发伴随神经元活动变化的代谢和血管变化的信号上。该领域的进展表明，主要兴奋性神经递质谷氨酸的释放启动了神经元和星形胶质细胞之间的多种信号传导过程，并且这种信号传导可能对脑成像信号的产生至关重要。在本文中，我们综述了谷氨酸是神经代谢和神经血管耦合的共同触发因素这一假说。
