Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo Street, ZNI115, Los Angeles, CA 90033, United States of America.
UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America.
Exp Neurol. 2019 Aug;318:78-91. doi: 10.1016/j.expneurol.2019.04.016. Epub 2019 May 2.
Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.
创伤性脑损伤是美国导致死亡和残疾的主要原因，并且可能与成年后长期的损伤有关。在大脑成熟过程中发生的大量持续神经生物学过程既使 TBI 具有相当大的易感性，但也可能提供适应性和恢复的潜力。本综述将在儿科 TBI 的背景下检查和综合我们目前对发育神经生物学的理解。阐明这种生物学将有助于更有针对性的初始治疗、基于机制的治疗干预以及更好的长期预后和随访。
