帕金森病中的重度抑郁症：一项基于登记处的研究。
Major depressive disorder in Parkinson's disease: a register-based study.
作者信息
Nilsson Flemming M, Kessing Lars V, Sørensen Tine M, Andersen Per K, Bolwig Tom G
机构信息
Department of Psychiatry, Rigshospitalet, University of Copenhagen, Denmark.
出版信息
Acta Psychiatr Scand. 2002 Sep;106(3):202-11. doi: 10.1034/j.1600-0447.2002.02229.x.
OBJECTIVE
To investigate whether patients with Parkinson's disease (PD) were at an increased risk of developing major depression compared with patients having other medical illnesses with a comparable degree of disability.
METHOD
Case register linkage study of Danish Psychiatric Central Register (DPCR)and Danish National Hospital Register (DNHR). Three study cohorts were identified: all patients with PD, osteoarthritis, and diabetes. The rate of discharge diagnosis of depression on re-admission was estimated using competing risks models in survival analyses. The rates for patients with PD were compared with those of patients with osteoarthritis, and diabetes.
RESULTS
The study sample identified 211 245 patients in the hospital registers with one of the index diagnoses. An increased incidence of developing depression was found for women and men throughout their lifetime when this incidence was compared with the control groups.
CONCLUSION
The findings support the hypothesis that depression in patients with PD is a consequence of brain dysfunction.
目的
探讨与具有同等残疾程度的其他内科疾病患者相比，帕金森病（PD）患者发生重度抑郁症的风险是否增加。
方法
丹麦精神病学中央登记处（DPCR）和丹麦国家医院登记处（DNHR）的病例登记联动研究。确定了三个研究队列：所有PD患者、骨关节炎患者和糖尿病患者。在生存分析中使用竞争风险模型估计再次入院时抑郁症出院诊断率。将PD患者的发生率与骨关节炎患者和糖尿病患者的发生率进行比较。
结果
研究样本在医院登记处识别出211245例具有索引诊断之一的患者。与对照组相比，发现男性和女性一生中患抑郁症的发生率均有所增加。
结论
研究结果支持以下假设，即PD患者的抑郁症是脑功能障碍的结果。
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