重度情感障碍患者患帕金森病的风险增加：一项登记研究。
Increased risk of developing Parkinson's disease for patients with major affective disorder: a register study.
作者信息
Nilsson F M, Kessing L V, Bolwig T G
机构信息
Department of Psychiatry, 0 6233, Rigshospitalet, Blegdamsvej 9, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark.
出版信息
Acta Psychiatr Scand. 2001 Nov;104(5):380-6. doi: 10.1034/j.1600-0447.2001.00372.x.
OBJECTIVE
To investigate whether patients with a diagnosis of affective disorder are at an increased risk of developing Parkinson's disease compared with medically ill control groups.
METHOD
By linkage of public hospital registers from 1977 to 1993, three study cohorts were identified: patients with affective disorder episodes (mania or depression) and patients with osteoarthritis or diabetes. Time to the first diagnosis of Parkinson's disease was estimated with the use of survival analysis.
RESULTS
A total of 164 385 patients entered the study base. The risk of being given a diagnosis of Parkinson's disease was significantly increased for patients with affective disorder, odds ratio 2.2 (CI 95% 1.7-2.8) compared with osteoarthritis, and depressive disorders, odds ratio 2.2 (CI 95% 1.7-2.9) compared with osteoarthritis.
CONCLUSION
This study supports the hypothesis of a common aetiology for major affective disorder and Parkinson's disease.
目的
研究与患有其他疾病的对照组相比，被诊断为情感障碍的患者患帕金森病的风险是否增加。
方法
通过链接1977年至1993年公立医院登记册，确定了三个研究队列：患有情感障碍发作（躁狂或抑郁）的患者以及患有骨关节炎或糖尿病的患者。使用生存分析估计首次诊断为帕金森病的时间。
结果
共有164385名患者进入研究基线。与骨关节炎患者相比，情感障碍患者被诊断为帕金森病的风险显著增加，优势比为2.2（95%置信区间为1.7 - 2.8）；与骨关节炎患者相比，抑郁症患者的优势比为2.2（95%置信区间为1.7 - 2.9）。
结论
本研究支持重度情感障碍和帕金森病存在共同病因的假说。
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