Demougeot Céline, Walker Paul, Beley Alain, Marie Christine, Rouaud Olivier, Giroud Maurice, Brunotte François
Laboratoire de Pharmacodynamie, Faculté de Pharmacie, BP 87 900, 21079 Dijon Cedex, France.
J Neurol Sci. 2002 Jul 15;199(1-2):73-8. doi: 10.1016/s0022-510x(02)00109-0.
Cerebral tissue with T2 magnetic resonance imaging (MRI) abnormalities following stroke is generally considered infarcted, while surrounding regions with normal MRI appearance are believed to be healthy. To assess whether these surrounding regions consist of normal tissue, we explored the distribution of N-acetylaspartate (NAA) and lactate within and around the hyperintense area on T2-weighted MRI using proton MR spectroscopy. The study was carried out in 25 patients with middle cerebral artery occlusion imaged between 1 and 42 days after stroke onset. NAA/choline (Cho) ratios were significantly reduced in both areas of T2 hyperintensity and in surrounding tissue. The reduction was greater in the region of T2 hyperintensity than in the surrounding region (-50% vs. -28%, respectively) and was unrelated to the delay after the ictus. Lactate/Cho ratios increased massively within the abnormal T2 area, but did not differ from control values beyond the margin of hyperintensity. Overall data indicate that T2 visible lesions on MRI do not infer the entire injured tissue.
中风后磁共振成像（MRI）T2序列显示异常的脑组织通常被认为是梗死灶，而MRI表现正常的周围区域则被认为是健康的。为了评估这些周围区域是否由正常组织构成，我们使用质子磁共振波谱探讨了T2加权MRI上高信号区域内及周围N-乙酰天门冬氨酸（NAA）和乳酸的分布情况。该研究纳入了25例大脑中动脉闭塞患者，在卒中发作后1至42天进行成像。T2高信号区域及周围组织中NAA/胆碱（Cho）比值均显著降低。T2高信号区域的降低幅度大于周围区域（分别为-50%和-28%），且与发病后的延迟时间无关。乳酸/Cho比值在异常T2区域内大幅升高，但在高信号边缘以外与对照值无差异。总体数据表明，MRI上T2可见病变并不意味着整个受损组织情况。
