前列腺素E1和F2α对离体肺内血管平滑肌的作用。

Actions of prostaglandins E1 and F2alpha on isolated intrapulmonary vascular smooth muscle.

作者信息

Joiner P D, Kadowitz P J, Hughes J P, Hyman A L

出版信息

Proc Soc Exp Biol Med. 1975 Nov;150(2):414-21. doi: 10.3181/00379727-150-39047.

PMID:1208557

Abstract

The effects of PGE1 and PGF2alpha were studied on isolated strips of intrapulmonary arteries and veins from dog, sheep, swine and man. PGF2alpha contracted human arterial strips in a dose-dependent fashion, relaxed slightly sheep arteries and had no effect on dog arteries. Canine, sheep and human venous strips were contracted by PGF2alpha. PGE1 relaxed slightly both veins and arteries from dog and sheep. Human arteries usually contracted slightly and human veins usually relaxed slightly to PGE1. In a limited number of experiments, swine arteries and veins failed to respond to PGF2alpha or PGE1. All the vascular strips contracted well when exposed to NE. These results suggest that the responses of intrapulmonary vessels to PGF2alpha and PGE1 are species-dependent. PGF2alpha generally exhibits a contractile action, especially on veins. PGE1 usually relaxes intrapulmonary vessels. With regard to vessels from man, PGF2alpha is a powerful stimulant while PGE1 produces only small, variable effects.

摘要

研究了前列腺素E1（PGE1）和前列腺素F2α（PGF2α）对犬、羊、猪和人离体肺内动脉和静脉条的作用。PGF2α以剂量依赖性方式使人类动脉条收缩，使绵羊动脉轻度舒张，对犬动脉无作用。PGF2α使犬、羊和人类静脉条收缩。PGE1使犬和羊的静脉和动脉均轻度舒张。人类动脉通常对PGE1轻度收缩，人类静脉通常对PGE1轻度舒张。在有限的实验中，猪的动脉和静脉对PGF2α或PGE1无反应。当暴露于去甲肾上腺素（NE）时，所有血管条均收缩良好。这些结果表明，肺内血管对PGF2α和PGE1的反应具有种属依赖性。PGF2α通常表现出收缩作用，尤其是对静脉。PGE1通常使肺内血管舒张。对于人类血管，PGF2α是一种强大的刺激物，而PGE1仅产生微小的、可变的作用。