Chand N, Eyre P
Agents Actions. 1979 Apr;9(1):4-8. doi: 10.1007/BF02024088.
Adult dogs were sensitized to horse plasma. Reactivity of isolated bronchus and pulmonary blood vessels to antigen and some selected autonomic and autacoid agents were studied. Pulmonary veins contracted to bradykinin, 5-HT, PGF2alpha, PGE2, histamine, carbachol and antigen (Schultz-Dale reaction). Pulmonary arterial strips contracted to 5-HT and histamine, but only weakly to horse plasma. Bronchial strips contracted to carbachol, 5-HT, histamine and horse plasma, relaxed to isoprenaline, PGE1 and PGE2. Subsequent antigen challenge produced 'desensitization'. Allowing the tissues to 'rest' for 1 and 2 h resulted in partial 'recovery' of the anaphylactic response. This investigation suggests that the contractions of sensitized pulmonary vein and bronchus to specific antigen may contribute to the patho-physiology of pulmonary hypersensitivity in dogs.
成年犬对马血浆致敏。研究了分离的支气管和肺血管对抗原以及一些选定的自主神经和自体活性物质的反应性。肺静脉对缓激肽、5-羟色胺、前列腺素F2α、前列腺素E2、组胺、卡巴胆碱和抗原（舒尔茨-戴尔反应）产生收缩反应。肺动脉条对5-羟色胺和组胺产生收缩反应，但对马血浆的反应较弱。支气管条对卡巴胆碱、5-羟色胺、组胺和马血浆产生收缩反应，对异丙肾上腺素、前列腺素E1和前列腺素E2产生舒张反应。随后的抗原激发导致“脱敏”。让组织“休息”1小时和2小时会使过敏反应部分“恢复”。这项研究表明，致敏的肺静脉和支气管对特定抗原的收缩可能有助于犬肺部超敏反应的病理生理学过程。
