治疗对自发性高血压大鼠寿命的影响。

Effect of treatment on longevity in spontaneously hypertensive rats.

作者信息

Freis E D, Ragan D

出版信息

Proc Soc Exp Biol Med. 1975 Nov;150(2):422-4. doi: 10.3181/00379727-150-39048.

PMID:1208558

Abstract

Continuous control of the pressure of spontaneously hypertensive rats at systolic levels of 90-100 mm Hg with antihypertensive agents significantly prolonged their life span. The mean survival time in control animals was 73 weeks as compared to 96 weeks in treated SHR (P less than .0005) with 11% of the latter surviving to approximately 3 yr of age. Cardiovascular lesions were limited almost exclusively to the control rats. The general health, body weight and reproductive functions of the experimental animals remained normal throughout the drug treatment. These results indicate that by preventing the rise in blood pressure and consequent cardiovascular complications the life span of the SHR may be prolonged to that of the normal albino rat.

摘要

用抗高血压药物将自发性高血压大鼠的收缩压持续控制在90 - 100 mmHg水平可显著延长其寿命。对照动物的平均存活时间为73周，而接受治疗的自发性高血压大鼠为96周（P小于0.0005），后者中有11%存活至约3岁。心血管病变几乎仅局限于对照大鼠。在整个药物治疗过程中，实验动物的总体健康状况、体重和生殖功能均保持正常。这些结果表明，通过防止血压升高及随之而来的心血管并发症，自发性高血压大鼠的寿命可延长至正常白化大鼠的寿命。