自发性高血压大鼠（SHR）和易卒中型大鼠（SPR）垂体-甲状腺轴的先天性异常。
Congenital abnormality of pituitary-thyroid axis in spontaneously hypertensive rats (SHR) and stroke-prone rats (SPR).
作者信息
Kojima A, Kubota T, Sato A, Yamada T, Yamori Y, Okamoto K
出版信息
Proc Soc Exp Biol Med. 1975 Dec;150(3):571-3. doi: 10.3181/00379727-150-39081.
In an attempt to study whether TSH abnormality was genetically determined in SHR and SPR, plasma T4, T3, TSH and prolactin concentrations were measured in the animals with intervals of 1 to 3 months. Hypertension was found in 6-month-old SHR and SPR, but it was not found in younger animals. In contrast, a decrease of plasma T3 and an increase of plasma TSH were found in 15-day-old SHR. Also, an increase of TSH was found in 1-month-old SPR in spite of normal plasma T3 concentration. These abnormalities in SHR and SPR increased progressively with age. It is suggested that thyroid-pituitary abnormality was genetically determined in SHR and SPR.
为了研究自发性高血压大鼠（SHR）和自发性高血压大鼠品系（SPR）的促甲状腺激素（TSH）异常是否由基因决定，每隔1至3个月测量这些动物的血浆甲状腺素（T4）、三碘甲状腺原氨酸（T3）、促甲状腺激素和催乳素浓度。在6月龄的SHR和SPR中发现了高血压，但在较年幼的动物中未发现。相反，在15日龄的SHR中发现血浆T3降低和血浆TSH升高。此外，尽管血浆T3浓度正常，但在1月龄的SPR中发现TSH升高。SHR和SPR中的这些异常随年龄增长而逐渐加重。提示SHR和SPR的甲状腺-垂体异常是由基因决定的。
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