冈本自发性高血压中内脏平滑肌异常的证据。

Evidence for a visceral smooth muscle abnormality in Okamoto spontaneous hypertension.

作者信息

Altman J, Da Ponte F, Worcel M

出版信息

Br J Pharmacol. 1977 Apr;59(4):621-5. doi: 10.1111/j.1476-5381.1977.tb07730.x.

DOI:10.1111/j.1476-5381.1977.tb07730.x

PMID:870125

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667751/

Abstract

In order to discover whether the changes in reactivity are related to the primary cause of hypertension in spontaneously hypertensive rats (SHR) or are just an adaptation induced by the high arterial blood pressure we tested the contractile response of a visceral smooth muscle from such rats. 2. Longitudinal strips of the fundus from 20 week old male and female SHR and Wistar normotensive (NW) rats were used. Dose-response curves to Ba2+ in SHR strips were displaced to the right as compared to NW rats. Maximal responses were identical. Male SHR fundus strips contracted much more with Sr2+ (SHR: 42+/-3% of maximum response to Ba2+, n=10; NW: 19+/-4%, n=10, P less than 0.01) than NW strips. There was no difference in the response to both BaCl2 and SrCl2 between female SHR and NW fundus strips, and MnCl2 and LaCl3 were relaxant in all cases. 3. Dose-response curves to Ca2+ of depolarized SHR and NW fundus strips were obtained and the effect of diazoxide on Ca2+ contractions was observed. The contractile action of Ca2+ in depolarized preparations was enhanced in both male and female SHR strips. The effect of diazoxide was more marked in SHR strips than in NW fundus strips. 4. SHR fundus smooth muscle shows the same modification of reactivity to Ba2+, Sr2+, Ca2+ and diazoxide that was previously described in arterial smooth muscle. This indicates that the cellular modification responsible for the increase of vascular tonus in SHR is not an adaptive reaction to high blood pressure. The differences between female SHR and male SHR responses are not unexpected, considering the natural evolution of hypertension in Okamoto rats which is milder in the female.

摘要

为了探究反应性的变化是与自发性高血压大鼠（SHR）高血压的主要病因相关，还是仅仅是由高动脉血压诱导的一种适应性变化，我们测试了来自此类大鼠的内脏平滑肌的收缩反应。2. 使用了20周龄雄性和雌性SHR以及Wistar正常血压（NW）大鼠的胃底纵行肌条。与NW大鼠相比，SHR肌条对Ba2+的剂量-反应曲线向右移位。最大反应相同。雄性SHR胃底肌条对Sr2+的收缩反应（SHR：对Ba2+最大反应的42±3%，n = 10；NW：19±4%，n = 10，P<0.01）比NW肌条大得多。雌性SHR和NW胃底肌条对BaCl2和SrCl2的反应没有差异，并且在所有情况下MnCl2和LaCl3都是舒张剂。3. 获得了去极化的SHR和NW胃底肌条对Ca2+的剂量-反应曲线，并观察了二氮嗪对Ca2+收缩的影响。在雄性和雌性SHR肌条中，去极化制剂中Ca2+的收缩作用均增强。二氮嗪在SHR肌条中的作用比在NW胃底肌条中更明显。4. SHR胃底平滑肌对Ba2+、Sr2+、Ca2+和二氮嗪的反应性变化与先前在动脉平滑肌中描述的相同。这表明导致SHR血管张力增加的细胞变化不是对高血压的适应性反应。考虑到冈本大鼠高血压的自然演变在雌性中较轻，雌性SHR和雄性SHR反应之间的差异并不意外。