Maral I, Cirak M, Aksakal F N, Baykan Z, Kayikcioglu F, Bumin M A
Department of Public Health, Gazi University Faculty of Medicine, Ankara, Turkey.
Eur J Epidemiol. 2001;17(7):661-5. doi: 10.1023/a:1015507402480.
The objective of this study was to determine the tetanus immunity status of pregnant women at the time of delivery according to tetanus toxoid (TT) vaccination coverage during their most pregnancy. The serum anti-tetanus antibody levels of 493 mothers who had live births at a hospital in Ankara were determined by enzyme-linked immunosorbent assay (ELISA). Protected women were defined as those with serum antibody levels > or = 0.6 IU/ml. Overall, 69.0% of mothers had protective tetanus antibody titers at the time of delivery. The rates of protection for mothers who had received no vaccination, one TT dose, or two TT doses during pregnancy were 46.4, 93.5, and 95.6%, respectively. Vaccinating every pregnant woman with at least one dose of TT would be an affordable and effective way to protect against neonatal tetanus, and would be a step toward eliminating the deaths that continue to occur due to this preventable disease in Turkey.
本研究的目的是根据孕妇孕期破伤风类毒素（TT）疫苗接种覆盖率，确定分娩时孕妇的破伤风免疫状况。采用酶联免疫吸附测定（ELISA）法测定了在安卡拉一家医院顺产的493名母亲的血清抗破伤风抗体水平。抗体水平≥0.6 IU/ml的女性被定义为具有保护性的女性。总体而言，69.0%的母亲在分娩时具有保护性破伤风抗体滴度。孕期未接种疫苗、接种一剂TT或两剂TT的母亲的保护率分别为46.4%、93.5%和95.6%。给每位孕妇接种至少一剂TT将是预防新生儿破伤风的一种经济有效的方法，并且将朝着消除土耳其因这种可预防疾病而持续发生的死亡迈进一步。
