Madico G, Salazar G, McDonald J, Checkley W, Calderón M, Verastegui M, Gilman R H
A.B. PRISMA, Lima, Peru.
Clin Diagn Lab Immunol. 1996 Nov;3(6):753-5. doi: 10.1128/cdli.3.6.753-755.1996.
In developing countries, neonatal tetanus causes significant mortality. Using a new competitive enzyme-linked immunosorbent assay to measure anti-tetanus toxin antibody levels, we compared rates of protection, total antibody levels, and maternal-to-fetal antibody ratios between different socioeconomic groups in Peru. Upper-middle-class women 25 years and older had significantly lower rates of protection and mean anti-tetanus toxin antibody levels than did lower-class women of the same age. Nevertheless, the former had higher fetal-to-maternal antibody ratios, independent of maternal age, total antibody levels, or parity. We conclude that future vaccination programs in Latin America must target upper-middle-class as well as lower-class women.
在发展中国家，新生儿破伤风导致了很高的死亡率。我们采用一种新的竞争性酶联免疫吸附测定法来检测抗破伤风毒素抗体水平，比较了秘鲁不同社会经济群体之间的保护率、总抗体水平以及母婴抗体比率。25岁及以上的中上层阶级女性的保护率和平均抗破伤风毒素抗体水平显著低于同年龄段的下层阶级女性。然而，前者的胎儿与母体抗体比率更高，且不受母亲年龄、总抗体水平或产次的影响。我们得出结论，拉丁美洲未来的疫苗接种计划必须同时针对中上层阶级和下层阶级女性。
