γ-丁内酯睡眠：与大鼠正常睡眠及中枢神经系统胺类变化平行的24小时节律。
Gamma-butyrolactone sleep: A 24-hour rhythm paralleling normal sleep in the rat and CNS amine changes.
作者信息
Speciale S G, Friedman A H
出版信息
Pharmacol Biochem Behav. 1975 Sep-Oct;3(5):761-4. doi: 10.1016/0091-3057(75)90103-3.
PMID:1208618
Abstract
The duration of sleep induced by a fixed dose of gamma-butyrolactone (GBL) (350 mg/kg, IP) FOllows the normal circadian sleep pattern of rats. GBL sleep duration is maximal at 1800 hr and minimal at 0600 hr. CNS amine changes are not extensive, but when normal sleep is anticipated, GBL treatment increases dopamine and serotonin levels and decreases norepinephrine levels.
摘要
固定剂量的γ-丁内酯（GBL）（350毫克/千克，腹腔注射）诱导的睡眠时间遵循大鼠正常的昼夜睡眠模式。GBL睡眠时间在18:00时最长，在06:00时最短。中枢神经系统胺类变化不广泛，但在预期正常睡眠时，GBL治疗会增加多巴胺和血清素水平，并降低去甲肾上腺素水平。
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