Stavropoulos F, Katz J
Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, Florida, USA.
Dentomaxillofac Radiol. 2002 Jul;31(4):213-7. doi: 10.1038/sj.dmfr.4600700.
The radiographic characteristics of central giant cell granuloma (CGCG) vary to a great extent. This study sought to relate the radiographic and clinical features of several cases, which were confirmed histopathologically, as central giant cell granulomas, and to systematically review the relevant literature.
Twenty cases with an established histopathological diagnosis of CGCG were received from the Department of Oral Pathology. The correlation between any two categorical variables was tested using Chi-square or Fischer's test, with alpha=0.01. A systematic review of the literature was performed using electronic and manual searches.
There was no gender predominance. Nearly 81% of the lesions were located in the deciduous tooth bearing area of the mandible and in 35% of the cases the lesions crossed the midline. The correlation between the size of the lesion and its appearance was statistically significant with larger lesions assuming a multilocular appearance. Most lesions (55%) were radiolucent while wispy opacification and trabeculation was evident in 50% of the lesions. The borders of the lesions were well defined in 65% of the cases and scalloping was seen in 53%. Displacement of teeth and/or other anatomic structures was seen in 50% of the cases while root resorption was found in 37%. The lesions perforated the cortex in 50% of the cases. Two cases, presented with paresthesia of the lip.
Central giant cell granuloma demonstrates clinical and radiographic features of a benign lesion with some aggressive characteristics.
中央巨细胞肉芽肿（CGCG）的影像学特征差异很大。本研究旨在关联经组织病理学确诊为中央巨细胞肉芽肿的几例病例的影像学和临床特征，并对相关文献进行系统综述。
从口腔病理学部门接收了20例经组织病理学确诊为CGCG的病例。使用卡方检验或费舍尔检验对任意两个分类变量之间的相关性进行检验，α=0.01。通过电子检索和手动检索对文献进行系统综述。
无性别优势。近81%的病变位于下颌乳牙列区域，35%的病例病变跨越中线。病变大小与其外观之间的相关性具有统计学意义，较大的病变呈现多房外观。大多数病变（55%）呈透射性，50%的病变可见纤细的致密影和骨小梁。65%的病例病变边界清晰，53%可见扇贝样改变。50%的病例可见牙齿和/或其他解剖结构移位，37%发现牙根吸收。50%的病例病变穿破皮质。2例出现唇部感觉异常。
中央巨细胞肉芽肿表现为具有一些侵袭性特征的良性病变的临床和影像学特征。
