Gautam Swati, Grewal Meetkamal, Saini Nitin, Arora Karandeep Singh
Department of Oral Pathology and Microbiology, Bhojia Dental College and Hospital, Baddi, India.
Department of Oral Pathology and Microbiology, BRS Dental College and Hospital, Panchkula, India.
BMJ Case Rep. 2019 Aug 13;12(8):e230847. doi: 10.1136/bcr-2019-230847.
Quite a few lesions of the oral cavity specifically of the gingiva have a greater inclination towards women and mostly occur during the first four decades of life, the cause of which may be credited to the changing levels of sex hormones. Out of all such lesions, one lesion whose aetiology is still unclear and which originats from the periosteum or periodontal ligament is central giant cell granuloma. Repeatedly, it is has been described as a reactive lesion, the cause of which may be secondary to local irritants or trauma, specifically plaque or calculus, which is not considered to be a true neoplasm. Here we present a case of a 51-year-old female patient with aggressive gingival growth within 10-13 months of hormonal replacement therapy. The aetiology, histological features and appropriate treatment are discussed in the light of current literature.
不少口腔病变，特别是牙龈病变，女性发病倾向更大，且大多发生在生命的前四十年，其原因可能归因于性激素水平的变化。在所有此类病变中，有一种病因仍不明确、起源于骨膜或牙周韧带的病变是中央巨细胞肉芽肿。它多次被描述为一种反应性病变，其病因可能继发于局部刺激物或创伤，特别是牙菌斑或牙结石，它不被认为是一种真正的肿瘤。在此，我们报告一例51岁女性患者，在激素替代治疗10 - 13个月内出现侵袭性牙龈生长。根据当前文献对其病因、组织学特征及适当治疗进行了讨论。
