Borodin A G, Baranov A A, Kliukvina N G, Abaĭtova N E, Nasonov E L
Ter Arkh. 2002;74(5):32-5.
To examine the level of tumor necrosis factor-alpha (TNFa) in the sera from patients with systemic lupus erythematosus (SLE) and its clinical and pathogenic role.
TNFa was measured with ELISA (Immunogenetics N.V., Belgium) in the sera from 147 SLE patients (70 men and 77 women). The results were compared with those of 20 healthy subjects.
TNFa elevated concentrations were found in 49% examinees with SLE. Concentration of TNFa, SLE activity and development of antiphospholipid syndrome correlated.
The findings indicate that TNFa is involved in pathogenesis of SLE. Quantitation of TNFa may serve a useful tool for monitoring SLE activity.
检测系统性红斑狼疮（SLE）患者血清中肿瘤坏死因子-α（TNFα）水平及其临床和致病作用。
采用酶联免疫吸附测定法（ELISA，比利时免疫遗传学公司）检测147例SLE患者（70例男性和77例女性）血清中的TNFα。将结果与20名健康受试者的结果进行比较。
49%的SLE受试者TNFα浓度升高。TNFα浓度、SLE活动度和抗磷脂综合征的发生相关。
研究结果表明TNFα参与SLE的发病机制。TNFα定量检测可能是监测SLE活动度的有用工具。
