Prokop'ev A A, Alekseeva T G, Zimina Z V, Ketlinskiĭ S A
Ter Arkh. 1993;65(5):9-12.
The contents of tumor necrosis factor alpha (TNF alpha) was measured by enzyme immunoassay in the serum from 43 healthy donors against 49 patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). In all the donors the cytokine did not reach 50 pg/ml, in SLE and RA running actively TNF alpha levels got elevated in the absence of previous long-term immunocorrection. Under the treatment effect blood levels of the cytokine fell in inhibition of the autoimmune process. Resistant to therapy patients with active rheumatic process kept for a long period on steroids exhibited TNF alpha concentrations less than 50 pg/ml. Low activity of the process and no need in corrective therapy were attended by normal TNF alpha content. The findings urge further efforts in the search for new approaches to SLE and RA treatment.
采用酶免疫分析法测定了43名健康供者以及49名系统性红斑狼疮（SLE）或类风湿关节炎（RA）患者血清中肿瘤坏死因子α（TNFα）的含量。在所有供者中，该细胞因子含量未达到50 pg/ml，在未经长期免疫纠正且处于活动期的SLE和RA患者中，TNFα水平升高。在治疗作用下，细胞因子的血液水平下降，自身免疫过程受到抑制。长期使用类固醇治疗的、对治疗有抵抗性的活动性风湿性疾病患者，其TNFα浓度低于50 pg/ml。疾病活动度低且无需进行纠正治疗的患者，其TNFα含量正常。这些发现促使人们进一步努力寻找治疗SLE和RA的新方法。
