Estrada Eréndira G, Ayala Alberto G, Lewis Valerie, Czerniak Bogdan
Department of Pathology, Instituto Nacional de Ortopedia, Mexico City, Mexico.
Ann Diagn Pathol. 2002 Jun;6(3):159-63. doi: 10.1053/adpa.2002.33905.
We report a case of dedifferentiated chondrosarcoma in which the dedifferentiated component of the tumor shows a close histologic resemblance to a conventional giant cell tumor of bone. The tumor affected a 30-year-old woman with a long history of left shoulder discomfort and limitation of motion. Radiographic studies revealed a biphasic destructive lesion in the left proximal humerus composed of high-signal lobulated component on T2-weighted magnetic resonance image accompanied by a low signal intensity component exhibiting destructive growth with extension into soft tissue. Microscopically, two different areas consisting of the chondroid tissue and nonchondroid giant cell-rich lesion resembling conventional giant cell tumor of bone were found. Considering that the prognosis and survival associated with these two entities are very different, it is important to be aware of this variant of dedifferentiated chondrosarcoma to avoid the misdiagnosis of conventional giant cell tumor of bone.
我们报告一例去分化软骨肉瘤病例，其中肿瘤的去分化成分在组织学上与传统骨巨细胞瘤极为相似。该肿瘤发生于一名30岁女性，她有长期左肩不适及活动受限病史。影像学检查显示左肱骨近端有一个双相性破坏性病变，在T2加权磁共振图像上由高信号分叶状成分组成，伴有低信号强度成分，呈破坏性生长并延伸至软组织。显微镜下，发现了两个不同区域，一个是软骨样组织，另一个是富含巨细胞的非软骨样病变，类似于传统骨巨细胞瘤。鉴于这两种实体的预后和生存率差异很大，认识到这种去分化软骨肉瘤变体以避免误诊为传统骨巨细胞瘤很重要。
